64. Cirrhosis. Etiology & pathogenesis. (etiology (genetic disease…
64. Cirrhosis. Etiology & pathogenesis.
CIRRHOSIS- irreversible distortion of normal liver architecture characterised by...
Drugs and poisons e.g. methotrexate and alcohol
viral hepatitis B, C and D
glycogen storage disease
congestive heart failure
increased/ altered collagen and CT synthesis in dev of hepatic fibrosis
fibrosis can affect hepatic blood flow and hepatocyte function
hepatic fibrosis occurs...
(to HBV infection)
(HA virus cause necrosis of hepatocytes). Fibrosis triggered by cytokine release from invading inflammatory cells
response to agents that induce
e.g. alcohol and iron (+) collagen gene transcription, (+) CT secreted by cells
1) change in EC matrix composition from non cross linked to dense cross linking form (reversible)
2) formation of sub-endothelial collagen crosslinks, proliferation of myoepithelial cells and distortion of hepatic architecture w/ regenerating nodules