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ANTI-COAGULANT DRUGS (AGENTS WHICH DECREASE BLOOD COAGULATION (INJECTABLE…

- - - - prior administration of drugs that induce P450 enzymes: barbitures, phenytoin
      - oral contraceptives
    - - inhibition of metabolizing enzymes
      - reduced availability vitamin K
      - liver disease/fever
      - drugs which impair paltelet aggregation: aspirin
      - drugs which displace plasma protein binding: aspirin and choral hydrate
    - - removal of Ca2+ willl inactivate key process in coagulation cascade
      - when transfused citrate is metabolized in Kreb's cycle
      - precipitate Ca2+ as insoluble chelate complex in vitro
- - - - activation by agonist: expression of GP IIb/IIIa that bind fibrinogen