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nucleus (nuclear envelope (nuclear pore complex (THE SPOKE RING (8 Tmp,…
nucleus
nuclear envelope
outer membrane
con't W/ rER
studded W/ ribosomes
TMP
inner membrane
associated W/ a NW of IF (nuclear lamina)
support NE
influences distribution of chromosome
perinuclear cisterna
b/t 2 membs
nuclear pore complex
THE SPOKE RING
8 Tmp
anchor NPC
project into nuclear pore lumen + perinuclear cisterna
NUCLEAR RING
8 sim prot SU
basket filaments
terminal ring
CYTOPLASMIC RING
8 similar protein SU
cytoplasmic filaments
transport
<9 nm
passive (diffusion)
both directions
9nm
active
1 D
receptors
nucleolus
fibrillar center (NOC)
pale area
inactive rRNA genes + RNA polymerase + transcriptional factors
pars fibrosa
active transcribed rRNA genes + RNA
dense area
pars granulosa
ribosomal subunits
nucleolar matrix
NW of fibers
Esse for nuclear organization
chromatin
euchromatin
active
extended
open face (vesicular) nucleus
LM
Light basophilic
EM
Dispersed filaments & granules (clear region)
Direct DNA replication & transcription
heterochromatin
inactive
condensed
closed face nucleus
barr's body (in active X female chromosome)
LM
Dense basophillic clumps
EM
ED fila & gran
Around nucleoulus
Peripheral
Islands
Func
Reserve
nucleosome
DNA strands coiled around 8 histones 2 times
11nm
beads-on-a-string shaped
chromatin packaging unit
can be packed into 30 nm chromatin fibers
chromosome
telomere
repeated nucleotide sequence
at end of chromosome
allow the full length of DNA to be replicated
help to protect DNA
replication origins
centromere
kinetochores assemble at centromere and bind mitotic spindle during mitosis
hold the duplicated chromosome together
Nucleoplasm (NM)
Colloidal prot solu
A medium for rapid diff’n of metabolites & RNA t/w pores