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25. Influenza (pathogenesis (single stranded RNA influenza virus…
25. Influenza
pathogenesis
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viral hemagglutinin attaches to receptors on ciliated epithelial cells, viral envelope fuses with cell, viral RNA enters cell.
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formed visions bud from infected cell and released by viral neuraminidase, infect ciliated epithelium and mucus and alveolar cells
infected cells die, recovery of mucociliary escalator may take weeks
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epidemiology
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antibodies produced after infection primarily IgG and must be sufficient in conc at site of invasion
appear 7 days after attack, max at 2 weeks
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