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epidermis (melanocyte (func (DOPA rxn (DOPA + tyrosinase ---> melanin,…
epidermis
melanocyte
origin
neural crest
site
basal layer
hair follicle
func
production of melanin
DOPA rxn
DOPA + tyrosinase ---> melanin
melonocyte
keratinocyte
cytocrine secretion
injection of melanosomes in neighbouring cells
structure
EM
cytoplasmic processes
hemidesmosomes
ED granules of melanin
no KF
No des
langerhan's cell
origin
macrophages
structure
LM
black, irregular N
clear cytoplasm
stellated, dentretic form
EM
irregular, folded N
Lysosomes & vesicles
bribeck granules
tennis racket
vermiform
receptor mediated endocytosis
no desmosomes/ hemidesmosomes/ KF
processing, branching cells
func
APC (bind & process & present) --> immuneresponse & cutaneous response hypersensivity rxn
site
stratum spinosum
merkel's cell
origin
neural crest
site
basal layer
func
perception og light touch
merkel's disc (MC + SN)
structure
LM
attached to KC by
processes
desmosomes
keratinocyte
5 strata
basalis
germinativum
LM
deep basophilia
oval, basal N
low columnar cell
EM
polysome
desmosomes
hemidesmosomes
spinosum
prickle cell layer
persist friction
EM
keratin filaments
higher desmosomes
lamellated gr. (LP & GP)
LM
basophilia
spherical N
spinous, polyhedral cell
granulosum
granular layer
EM
ED kertohyalin granules
matrix for pairing KF
lamellated gr
water proof barrier
LM
basophilia
flat cell
flat N
deeply basophilic keratohyaline gr
lucida (3-5 L)
clear zone
LM
acidophilia
flat cells
EM
degenerating organelles
...
Corneum
horny layer
EM
keratin
R. desmosomes
LM
deep acidophilia
no organelles