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Drug for asthma (Mitigate inflammation (抑制肥大細胞 (Cromolyn,Nedocromil…
Drug for asthma
Mitigate inflammation
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Steroid
Glucocorticoid
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Prednisolone,Prednisone:嚴重氣喘時使用
1.抑制免疫,降低巨噬,嗜酸,淋巴球參與發炎的數目和反應,減少釋放細胞激素,血管收縮,減少黏液分泌
2.減少平滑肌敏感性:針對過敏原,刺激物,冷空氣,運動等等
3.對平滑肌收縮無直接作用
4.upregulation for beta adrenergic receptor
Inhaled
Beclomethasone,Budesonide,Flunisolide,Fluticasone,Mometasone,Triamcinolone:中度氣喘用吸入給藥 (10%成功作用)
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抑制肥大細胞
Cromolyn,Nedocromil :預防性噴霧
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Relax smooth muscle
PDE inhibitor
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1.抑制cAMP to AMP, 所以cAMP使氣管放鬆
2.adenosine receptor antagonist
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Muscarinic receptor
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不能使用atropine,因為太多副作用,cause miscues plug,而且不會造成氣管舒張
(氣喘的氣管受損是Leukotriene造成的,不是Muscarinic receptor stimulation)
Beta 2 agonist
1.直接作用在呼吸道使氣管舒張
2.活化AC, cause ATP to cAMP
短期
15-30分鐘
Fenoterol,Metaproterenol,Abuterol,Salbutamol,Terbutaline,Bitolterol,Pirbuterol
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