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Antagonism (Types (Receptor (Types (Non-competitive (Allosteric) (bind to…

- - - - competitive
        
        Chemically similar to agonist , compet with it & bind to same site
        
        Antagonist have affinity but no intrinsic activity, no response is produced and log DRC of agonist is shifted to right
        
        antagonist binding is reversible and depend on relative conc of agonist and antagonist molecules
        
        e.g. Ach - atropine , Morphine - naloxone
      - Non-competitive (Allosteric)
        
        bind to a allosteric site and altered the binding site so agonist can not bind
        
        increase conc of antagonist progressively flatten agonist DRS
        
        Increase conc of agonist can not reverse block
        
        Not in clinical use :red_cross:
        
        e.g. Diazepam - Bicuculline
      - Non-equilibrium
        
        certain agonist bind to receptor with strong bond or dissociate from it slowly , so that agonist molecule unable to reduce receptor occupancy of antagonist molecule
        
        Agonist DRC shifted right and maximal response is lowered
        
        Also called a type of noncompetitive antagonism