pervois fracture at 20-50y,
hip fractue in 1st relatives,
smoke,
gonadal defic (early meno + prolonged amenhor),
low wieght or loss,
long gcs use,
low Ca diet.
Other: system disease (hyper-T3, hyper-PTH,, hyper-GCS, IBD, celiac, primary bile cirhosis, Dm2), drugs (heparin, anoxilytic, anticonculsant, neurolpetic), life (consump high level caffieni + alcohol, sedentary life).