Hyperkalaemia: made worse by renal disease and drugs that inhibit renin (β-blockers, NSAIDs, aliskiren) or AII activity (ACE inhibitor, ATR antagonists)
Hyperchloremic metabolic acidosis: cause acidosis by inhibiting H+ secretion from intercalated cells together with K+ secretion. (Normal anion gap (other anion conc constant), a decrease in plasma bicarbonate concentration, and an increase in plasma chloride concentration. Non–anion gap acidosis occurs in situations in which HCO3− is lost from the kidney or the gastrointestinal tract or both. When this occurs, Cl− (along with Na+) is reabsorbed to replace the HCO3−; this leads to the hyperchloremia, which leaves the anion gap in normal range
Gynaecomastia: through interaction of spironolactone with other steroid receptors: also impotence and BPH: not reported for eplerenone
Acute Renal Failure: combination of triamterene with indomethacin
Kidney stones: triamterene limited solubility: may precipitate in urine