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organelles (peroxisome (produce E t/r b-oxidation of FA (no ATP/ inst.…

- - - - early then late endosome
    - - phagosome fuse with LE
    - - autophagosome (memb from ER) fuse W/ LE
  - - - vary
        
        ED
        
        intermingling
- - - - H&E
        
        acidophilia
      - silver.s
        
        rods
        
        filaments
        
        granules
    - - memb
        
        outer
        
        porins (channel )
        
        prot. synt. & met. of lipid
        
        inner
        
        folded -> SA
        
        cristae
        
        tubular (SSC)
        
        flat, shelf-like (most cells)
        
        ATP Synt. (lolipop-like)
        
        respiratory.C pumps
        
        transfer H+ into IMS
        
        impermeable
      - space
        
        intermembranous
        
        part. in ATP synthesis
        
        trigger PCD when rel. into cytosol
        
        matrix
        
        DNA
        
        matrix granules (may bind cal & mag)
        
        ribosomes
        
        enzymes OF
        
        CAC
        
        B-oxidation
  - - - most MP encoded by NDNA
      - synt. some of their str'l Prot.
- - - - basophilia
        
        spotty (nissl granules)
        
        localized (BP of ESC)
        
        Intense (growing, dividing cells)
    - - ED granules
        
        small subunit
        
        1 rRNA
        
        33 prot
        
        large subunit
        
        3 rRNA
        
        49 prot
        
        rRNA in nucleolus
        
        prot associated with rRNA in nucleoplasm
        
        ribosomal subunits bind only in cytoplasm during BS of prot.
  - - - 10 + mRNA thread
      - cytosolic prot.
        
        Hb in RBCs.
      - peroxisomal prot.
    - - secretory prot
      - lysosomal prot
      - membranous prot
    - - reserve
- - - - LM
        
        basophilia
      - EM
        
        interconnected
        
        flat
        
        saclike
        
        cisternae
        
        cont W/outer memb of NE
        
        studded with ribosomes
    - - syn. prot (secretory, PM, lysosomal)
      - modification (folding, sulfation, phosphorylation, initial glycosylation)
      - transport to GA
    - - liver cells
      - secreting cells
  - - - LM
        
        acidophilia
      - EM
        
        interconnected
        
        vesicles & tubules
        
        branching
        
        cont W/ rER memb
        
        no ribosomes attached
    - - synt. lipids & SH & glycogen
      - detoxification
      - store & reg. ca++
      - HCL formation
    - - liver cells
      - steroid secreting cells
      - muscle cells
- - - - H&E
        
        NGI
      - SILVER STAIN
        
        fine brownish granules
    - - stacks composed of (4-6) curved saclike cisternae
      - faces
        
        cis (immature) face
        
        convex
        
        trans (mature) face
        
        concave
      - components
        
        CGN
        
        CGC
        
        MGC
        
        TGC
        
        TGN
  - - - glycosylation
    - - lysosomes
        
        clathrin coated
      - secretory vesicles
      - PM
- - - - ligands move to LE
      - receptors recycled
      - ligands & receptors separate
  - - - become lysosomes