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Myopathies (Polymyositis (PM) (Presentation (Proximal muscle weakness,…

- - - - Rashes
        
        Heliotrope
        
        Gottron's Papules (knuckles)
        
        Gottron's sign (elbows/knees)
        
        Shawl/V sign
        
        Holster sign
      - Periungal
        
        Cuticular hypertrophy
        
        Abnormal nailfold capillaries
      - Calcinosis cutis (children)
      - Mechanics Hands
        
        ^ prev: arthritis, ILD, fever, Raynaud's
        
        Onset: Acute, severe. Moderate response to therapy.
        
        Anti-Jo1 antibodies (AKA anti-histidyl-tRNA synthetase)
        
        POOR prognosis
- - - - EMG/NCS
      - MRI for inflamm/infxn
      - Biopsy: gold standard. Avg 2-3 needed before (+) biopsy found.
        
        Endomysial infiltrates
        
        CD8+
        
        Rimmed vacuoles