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Oncogenes & Tumor Suppressor Genes (ONCOGENES (Point mutations (Ras…
Oncogenes & Tumor Suppressor Genes
ONCOGENES
Dominant
Point mutations
Ras family
Translocations
Bcr/Abl
Positive effect on growth
Esempi e cosa sono
Identification
PI3K pathway
TSG
Recessive – loss of function
Familial Cancer Syndromes
Dna repair syndromes
Inactivation
Loss of Heterozygosity
Two-hit hypothesis
predisposizione & famiglie
Rb