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Sarcoidosis (Epidemiology (10-20/100,000, African Americans 2.4% Whites 0…
Sarcoidosis
Epidemiology
10-20/100,000
African Americans 2.4% Whites 0.85%
AA more acute, severe disease
Whites tend to be asymptomatic
Genetic component
Symptoms
50% incidental finding on CXR
Lung most commonly involved
Cough
DOE
Chest pain
Other systems (30%)
Cardiac
Myopathy
Conduction abnormality
Skin
Rashes (EN)
Joints
Arthritis (10%)
Eyes
Uveitis (25%)
Diagnosis
Biopsy
Gallium scan for uptake
Help find a place to biopsy
"Panda sign"
Labs
None reliable
ACE levels not helpful
Lofgren Syndrome
Symptoms (Triad)
Erythema Nodosum (EN)
Hilar adenopathy
Migratory polyarthralgia
95% diagnostic
specificity for sarcoidosis when triad present
Treatment
NSAIDs
Good prognosis. Remission likely.
Treatment
Steroids (Mainstay)
Steroid-Sparing
MTX
AZA
Anti-TNF
Remicaid
Humira
Screen
Eye disease
#
Heart disease