Hepatosplenomegaly, skeletal deformities, lesions of heart
valves, and subendothelial arterial deposits (particul in coronary arteries), and lesions in brain, in all of the MPSs. In many of more protracted syndromes, coronary subendothelial lesions--> myocardial ischemia--> myocardial infarction + cardiac decompensation important causes of death. Most cases: coarse facial features, clouding of the cornea, joint stiffness, and mental retardation. Urinary excretion of accumulated MPS often incr.