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Cytoskeleton (Actin (Functions (Microvilli (Fimbrin crosslinks), Membrane…

- - - - Fimbrin crosslinks
    - - Actin polymerization
    - - Focal adhesion, stress fiber assembly
  - - - Trimer
        
        Nucleation
    - - ATP is split while on the actin
    - - Midpoint b/t critical concentrations
        
        Adding to plus end
        
        Coming off minus end
  - - - Trimers
    - - Monomer binding
        
        Profilin
      - Generate actin filament bundles; short and inflexible
        
        Contractile bundles
        
        Widely spaced
        
        Found in...
        
        Muscle
        
        Stres fibers
        
        Myosin II; alpha-actinin
        
        Parallel bundles
        
        Closely spaced
        
        Found in...
        
        Filopodia
        
        Microvilli
        
        Fimbin
      - Filamin initiation, polymerization
        
        Arp2/3, formin
      - End capping
        
        CapZ, tropomodulin
      - Filamin stabilization
        
        tropomyosin, nebulin
      - Linkage to other proteins
        
        Vinculin, talin, spectin, dystrophin
      - Filament severing
        
        Cofilin
  - - - Stabilizes actin
        
        Prevents depolymerization
        
        Prevents movement
    - - Block barbed end of actin
        
        Prevents elongation
- - - - Head-tail of tubulin dimers
- - - - Epithelial cells