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Development of cancer (2 pathways (Hyperactive (Dominant effect (Proto…
Development of cancer
2 pathways
Hyperactive
Dominant effect
Proto-oncogene becomes oncogene
Inactive
Recessive
Inhibitory gene becomes inactive
Tumor suppressors
Ras pathway
Ras and GDP/GTP
Rxn 1: SOS or GEF
Rxn 2: GTPase or Ras
Ras a GDP/GTP
Rxn 1: SOS or GEF
Rxn 2: Suppressed; no Ras GTPase
Ras stays active
Persistent mitogenic signal
Single-cell origin
Excessive cell proliferation
Proto-oncogene becomes oncogene
Growth stimulatory pathway