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Transport in Animals (The Structure of the Heart (External Features…
Transport in Animals
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Transport of Oxygen
Haemoglobin
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Disassociation Curve
At low oxygen tension, haemoglobin doesn't readily associate with oxygen; the haem group is at the centre of the haemoglobin molecule making it difficult to combine with the first oxygen.
As oxygen tension rises, so goes the diffusion gradient causing the first oxygen to bind. This causes a conformational change in the haemoglobin shape so oxygen more readily associates with oxygen
At the highest oxygen tension, haemoglobin never becomes 100% saturate due to decreased probability of oxygen binding with the last haem group and that the partial pressure is never high enough for long enough to associate with the last oxygen
Fetal Haemoglobin
Fetal haemoglobin has a higher affinity to oxygen than adult haemoglobin, therefore its disassociation curve is more to the left
Oxygen tension is low in the placenta so when the fetal haemoglobin associates with the oxygen, the oxygen tension lowers in the mother blood, further dissociating oxygen from the mother's erythrocytes