also called House of Austria was one of the most influential and outstanding royal houses of Europe. The throne of the Holy Roman Empire was continuously occupied by the Habsburgs between 1438 and 1740. The house also produced emperors and kings of the Kingdom of Bohemia, Kingdom of England (Jure uxoris King), Kingdom of Germany, Kingdom of Hungary, Kingdom of Croatia, Second Mexican Empire, Kingdom of Ireland (Jure uxoris King), Kingdom of Portugal, and Spain, as well as rulers of several Dutch and Italian principalities.[dubious – discuss] From the 16th century, following the reign of Charles V, the dynasty was split between its Austrian and Spanish branches. Although they ruled distinct territories, they nevertheless maintained close relations and frequently intermarried.