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Nociception Assay (Pain) (Formalin (Scoring behaviours (after injection to…
Nociception Assay (Pain)
Formalin
Chemical = Formalin (saturated aqueous solution of formaldehyde)
Scoring behaviours (after injection to hindpaw)
Flinching
Licking
Biting
Stages
Acute
(directly after injection) = direct activation of nociceptors
Late / tonic phase
(15-20 mins after injection) = pain from inflammation
Advantages
Limited duration (1 h)
2 distinct phases (acute + tonic)
Thermal assays
Radiant heat tail-flick test
Hot plate test
Acid-induced visceral pain (writhing)
Chemical = 1% acetic acid (aq)
Method = Count no. of abdominal constrictions for 30 min after acid injection
Von Frey
Assessment of mechanical allodynia
Test for PNS (Peripheral Nervous System)