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Optical signal imaging (intrinsic (scatter (intra- and extra-cellular…
Optical signal imaging
chromophores
VSD
intrinsic
absorption
fluorescence
scatter
membrane conformation
intra- and extra-cellular compartments
due to the movement of ions and associated water molecules
auto-fluorescence
Two-Photon Functional Imaging
neurovascular coupling
light scattering
oxy- / desoxyhem
Article
Noninvasive
Topography
NIRS
Tomography
Methodological Extras
Cytochrome oxidase
?
topography vs tomography
2d vs 3d
nonionizing
radiation
less that UV
multispectral
optical imaging
two-photon microscopy
Exposed-Cortex
3D
2D
principles
intrinsic
blood
oxygenation
HbO/Hbr
main absorber
NIR
Vsisble
isoasbestic
=
Hb_tot
610
Hbr
Beer-Lambert law
vol
flow
hyperspectral
Methodological extras
Fast scattering signal.
Optical coherence tomography (OCT)
Laminar optical tomography (LOT)
Intrinsic fluorophore imaging
method
Two-Photon Microscopy
basic principles
3 основных процесса
рассеивание света
refractive indices of cytoplasm
membrane folding
organelle volume
organell size = wavelength (380-1000 nm)
ОВР хромофоров
гемоглобин
оксиметрия
оксигенация гемоглобина
цитохром-С-оксидаза
over 500 nm
объем крови и кровоток
Monte Carlo methods
3 tasks
numerical integration
draws from a probability distribution
optimization
randomness
NVC
