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Bacteria (Campylobacter jejuni (Found In (Contaminated water & food,…

- - - - SHRIMPS
- - - - Bacillary Dysentery
      - Shigella like enterotoxin
    - - Hemorrhagic Colitis
      - Hemolytic Uremic Syndrome
        
        Acute Renal Faliure
        
        Microangiopathic hemolytic anemia
        
        Thrombocytopenia
        
        Death
      - Shiga Toxins (Stx1 & Stx2)
      - O157:H7
        
        Heat sensitive but resistant to freezing
        
        Caused several large food poisoning outbreaks by Ground meats
    - - Traveller's Diarrhea
        
        Watery - Secretory
      - Heat labile & Heat stable toxin
      - Labile toxin related to cholera
        
        Activates adenylate cyclase (cAMP)
        
        Inc permeability to Na and Cl
      - Stable toxin
        
        Activates guanylate cyclase (cGMP)
        
        Dec absorption of Na & Cl
      - Toxins are coded by plasmid DNA
    - - Traveller's Diarrhea
      - Entero Aggressive heat stable enterotoxin
    - - Infantile Diarrhea
- - - - Chills, fever, malaise, aches, swollen lymph nodes
  - - - Typhoid fever - systemic
    - - food poisoning - self-limiting
    - - Complication of enterocolitis
  - - - Localized side effects & Systemic Symptoms (LPS)
      - 50-95% effective
        
        Exposure
        
        Personal History
    - - Chemically Mutagenized Strain
      - 60-70% protection
      - No protection
- - - - fecal-oral
      - person-person
    - - Fingers
      - Feces
      - Food
      - Flies
      - Water
    - - 10^8 CFU/gram of infected stool
  - - - high volume watery diarrhea
      - Lower Abdominal Cramps
    - - Dysentery
        
        Small volume bloody mucoid stool
        
        Fever
        
        Malaise
        
        Fatigue
        
        Anorexia
- - - - Rice
      - Spice
      - Mashed Potatoes
      - Herbs
      - Vegetables
      - Meat
      - Dairy
      - Eggs
      - Noodles
      - Soup
  - - - Hemolysin BL
      - Non-hemolytic
  - - - Nausea, Vomitting, Abdominal Cramps 1-6 hrs
    - - Profuse Diarrhea (watery stool)
      - Abdominal Cramps
      - Tenesmus
      - 8-16 hrs and resolves within 12 hrs