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Drug prototype (Morphine (Diamorphine (alternative to morphine substitute)…
Drug prototype
Morphine
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Apomorphine (emetic, treat poisoning & Parkinson, devoid morphine like activity)
Metopon (3x morphine, too expensive)
Nalorphine (Analgesic, non-addictive, restore normal respiration, reverse opiod overdose, cause hallucination)
Levorphanol (Absence O bridge - greater lipophilicity thus distribution - longer action duration, reabsortion - longer half life)
Levallorphan (10x nalorphine - greater lipholicity favoured entry into CNS, less common due to naxalone)
Dextromethorphan (Antitussive, codeine-like methy ester)
Phenazocine (3x morphine, similar additive potential to morphine, well adsorbed from GI, tablet for severe pain)
Pentazocine (1/3 morphine, low addictive liability, induce hallucination, for moderate pain)
Thebaine
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Etorphine (1000x morphine, high lipophilicity, not accompanied with greater safety, immobilize large mammal)
Buprenorphine (100x morphine, longer action duration due to affinity to receptor, lower dependence liability than codeine)
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Codeine
Ethyl morphine (more potent & longer acting, cough suppressant)
Pholcodine (Cough suppressant, similar activity, fewer side effects)