前列腺素 prostaglandin
功能Functions
合成synthesis
發燒Cause fever(PGE2)
控制腸胃道黏液及酸分泌increase mucus production and bicarbonate secretion
調節疼痛sensitize spinal neurons to pain
控制子宮收縮Promote the contraction of the uterus
調控發炎反應regulate inflammation
脂肪加氧酶途徑Lipoxygenase pathway
環氧合酶途徑
Cyclooxygenase pathway
COX-1
COX-2
常駐型酵素,負責自然生理製造
Constitute enzymes, responsible for the natural physiological manufacturing
誘發型酵素,在特定組織中存在,會因為慢性發炎而增加,受糖皮質素抑制
Inducible enzyme,Existence in specific tissues increases with chronic inflammation and is inhibited by glucocorticoids
藥物應用
Drug application
celecoxib
NSAIDs
可逆的抑制COX-1、COX-2
Reversible inhibition of COX-1、COX-2
抑制COX-2
Inhibit COX-2
aspirin
不可逆的抑制COX-1、COX-2
Irreversible inhibition of COX-1, COX-2
抑制血小板聚集與否 cause aggregation or disaggregation of platelets