前列腺素 prostaglandin

功能Functions

合成synthesis

發燒Cause fever(PGE2)

控制腸胃道黏液及酸分泌increase mucus production and bicarbonate secretion

調節疼痛sensitize spinal neurons to pain

控制子宮收縮Promote the contraction of the uterus

調控發炎反應regulate inflammation


脂肪加氧酶途徑Lipoxygenase pathway

環氧合酶途徑
Cyclooxygenase pathway

COX-1

COX-2

常駐型酵素,負責自然生理製造
Constitute enzymes, responsible for the natural physiological manufacturing

誘發型酵素,在特定組織中存在,會因為慢性發炎而增加,受糖皮質素抑制
Inducible enzyme,Existence in specific tissues increases with chronic inflammation and is inhibited by glucocorticoids

藥物應用
Drug application

celecoxib

NSAIDs

可逆的抑制COX-1、COX-2
Reversible inhibition of COX-1、COX-2

抑制COX-2


Inhibit COX-2

aspirin

不可逆的抑制COX-1、COX-2
Irreversible inhibition of COX-1, COX-2

抑制血小板聚集與否 cause aggregation or disaggregation of platelets