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Case 16.2 (Movement abnormalities (bilateral hyperkinetic movement…
Case 16.2
Movement abnormalities
Clumsiness
occassional stumbling
chorea
abnormal involuntary movement
irregular jerking movement of head, trunk and limbs
teeth grinding
noisy swallowing
bilateral hyperkinetic movement disorder
tremors
dystonia
muscles contract uncontrollably
tics
spasmodic contraction of muscles in face
myoclonus
twitches, jerks, seizures
bilateral dysfunction in subthalamic nuclei
dysfunction in striatal neurons of indirect pathway
Huntington's Disease
progressive atrophy of striatum
atrophy to both caudate nucleus and putamen
abnormalities in all 4 domains of basal ganglia
Limbic channel
oculomotor channel
motor channel
prefrontal channel
unsteady gait
abnormality of walking
autosomal dominant inheritance pattern
father died from huntington's disease
expanded CAG trinucleotide repeat in gene encoding huntington's disease
emotional changes
disinhibited behavior
argumentive
involvement of limbic channel
involvement of prefrontal channel
marital problems
saccadic eye movements
simultaneous movement of both eyes between 2 or more phases of fixation in same direction
involvement of oculomotor channel