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Potassium Balance (How maintained (Kidneys, 3.5-5mmol/l, Normal function…

- - - - Na+/K+ pump
        
        more where depleted
        
        less where in excess
      - Rate of flow
        
        As flow up; K+ secretion into filtrate up.
    - - Aldosterone increases K+ secretion
      - ADH; stim. secretion K+ by DT and CD; decreases urinary flow rate
    - - Acid Base status
        
        Acidosis
        
        Chronic; increased K+ secretion; hypokalaemia
        
        Acute; decreased K+ secretion; hyperkalaemia
        
        Alkalosis
        
        Chronic; stim. even more excretion K+; hypokalaemia
        
        Acute; stim. excretion K+; hypokalaemia
  - - - Hormones
        
        Insulin
        
        Aldosterone
        
        Epinephrine
    - - Cell lysis
      - Exercise
      - Increase plasma osmolality; release K+ from cells
      - Acid Base Balance; acidosis increases plasma K+
- - - - Direct; GIT
      - Indirect: Kidneys
        
        Stim. of aldosterone--> excretion K+
- - - - Plasma K+ rises
      - Hyperkalaemia reduces RMP
      - Decreases excitability of neurons
      - By lowering the threshold lower the no. Na channels open and change vMax
      - Speed of ustroke dependant on what no. channels open
    - - Lyse and burst of K+ into cell