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Liver cirrhosis (Causes of cirrhosis (Biliary diseases : 5-10%, Autoimmune…
Liver cirrhosis
Causes of cirrhosis
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- Alcoholic liver disease : 10%
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Viral hepatitis B , C & D : 60-70%
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Diffuse: means that all the liver must be fibrosis to call it cirrhosis. Focal injury with scarring is not cirrhosis
diffuse process characterized by fibrosis and the conversion of normal liver architecture into structurally abnormal nodules
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progressive fibrosis happens = deposition of collagen I and III = excess collagen comes from perisinusoidal stellate cells (Ito cells)
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Macro-nodular cirrhosis is clinically important because this is how it is diagnosed and not through biopsies
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