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Drugs used in constipation and diarrhoea (Antidiarrhoeals6 BLOCKS (Drugs…
Drugs used in constipation and diarrhoea
Laxatives7
(Drugs used for constipation)
Physical3 PMPhilDGMNB
Bulk-forming laxatives
Psyllium
Methycellulose
Polycarbophil
Stool surfactant agents
Docusate
Glycerin suppository
Mineral oil
Osmotic laxatives
Non-absorbable sugars or salts
Sugars: Sorbitol, lactulose
Salts: Magnesium hydroxide (milk of magnesia), Magnesium citrate, Sodium phosphate
Balanced Polyethene Glycol
Physiological4(3123)
Stimulant laxatives
Anthraquinine derivatives
Aloe, senna, cascara
Chronic use leads to brown pigmentation of colon (melanosis coli)
Diphenylmethane Derivatives
Bisacodyl
(oral or per rectum)
Chloride channel activators
Lubiprostone
Avoid in pregnancy
Opoid receptor antagonists
Methylnaltrexone bromide
Alvimopan
Serotonin 5-HT4-Receptor Agonist
Tegaserod
Cisapride
Adverse cardiovascular events due actions at hERG K+ channel
Prucalopride
Antidiarrhoeals6
BLOCKS
(Drugs for diarrhoea)
Opioid agonist
Loperamide, diphenoxylate
Colloidal bismuth compounds
Kaolin and pectin
Can bind to and inhibit absorption of other medications. Should not be taken within 2 hrs of other medication
Bile salt binding resin
Cholestryamine, colestipol, colesevelam
Somatostatin-like peptides
Octreotide
Lyophilizate of killed Lactobacillus acidophilus
Lacteol forte (oral capsule or powder mixed with water)
Contraindicated in patients with lactose intolerance as formulation contains lactose monohydrate
Adheres onto the surface of intestinal cells and normalizes the intestinal flora by competitive exclusion