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MAHA (Characteristics (Microangiopathic Haemolytic Anaemia, Aquired,…
MAHA
Characteristics
Microangiopathic Haemolytic Anaemia
Aquired
Mechanical destruction of RBCs
Often Thombocytopenia
Schistocytes (broke RBCs) on film
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Thrombotic Thrombocytopenia Purpura (TTP)
Rare
Emergency
Pentad Symptoms
Confusion
Thrombocytopenia
Renal Failure
MAHA on Blood Film
Fever
microthrombi (Lung/heart)
Treatment
FFP
ADAMTS-13
Disseminated intravascular coagulation (DIC)
Systemic activation of flotting
Coag factor depletion
Clots cause organ disfunction
Blood tests
Increased PT
Increased D-Dimer
increased APTT
Decreased Platelets
Treatment
Treat underlying cause
Trauma
Sepsis
Cancer
Toxins
FFP
Clotting factors