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Hirschsprung disease 2 (Clinical Features (delayed passage of meconium…
Hirschsprung disease
2
Morphology
Lack of ganglion cells
and ganglia in the muscle wall
and submucosa of the
affected segment
affected segment is not distended
proximal segment (properly innervated
Undergoes dilation – sometimes massively
with accumulation of stool in the proximal segment
stercoral ulcers.
chronic constipation
Hirschsprung disease
The wall may be
thickened by compensatory muscle
hypertrophy mainly in the proximal colon
trying to overcome the pressure and
try to achieve peristaltic movement
thinned by distention
Clinical Features
delayed passage
of meconium
meconium is the earliest stool of
a mammalian infant
followed by vomiting in 48 to 72 hours
in the pediatric age group
involvement of a very short segment of rectum
appear in later infancy,
Complications
Superimposed
enterocolitis
with fluid and
electrolyte disturbances
Perforation of the distended
colon & peritonitis,
create
megacolon
lead to
peritonitis