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Gastric Carcinoma 2 (Location: (-More common in the lesser curvature …
Gastric Carcinoma
2
Risk Factors:
Intestinal-type
adenocarcinoma
Pernicious anemia
(Autoimmune gastritis).
Diets containing foods
that may generate
nitrites that form
nitrosamines and
nitrosamides
(Smoked foods
pickled vegetables
excessive salt intake
Decreased intake
of fresh vegetables
and fruits
(antioxidants present
in these foods may
inhibit nitrosation
Infection with
Helicobacter pylor
Partial gastrectomy
Chronic gastritis
with intestina
l metaplasia
Diffuse-type adenocarcinoma
Rare inherited mutation of
E-cadherin
Infection with H. pylori and chronic gastritis often absent
Risk factors are undefined
Location:
, Cardia (25%)
Pylorus and antrum (50% to 60%)
body & fundus
-More common in
the lesser curvature
than the Greater curvature
Lesser curvature of the antropyloric region
Classification based
on depth of invasion:
-Early gastric
carcinoma (EGC)
could be
Exophytic,
Flat (depressed)
which leads to ulceration (that's why all
gastric ulceration must be biopsied)
Confined to the mucosa & submucosa
excavated which
leads to blood loss
because it affects
the BVs.
Exophytic
Flat (depressed)
excavated
Advanced gastric carcinoma
Evoke a desmoplastic reaction and
wall hardening
May mimic chronic peptic ulcer
that’s why we can't differentiate
endoscopically between malignant,
benign gastric ulce
Extended below the submucosa
Heaped-up (raised) margins
