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Squamous cell carcinoma (Risk Factors for SCC of the Esophagus chronic…
Squamous cell carcinoma
The most common type of esophageal
carcinoma
adults > 40-50 years
M>F
High incidence in Iran,
China & South Africa
Related to
diet
Barret’s and gastroesophageal
reflux disease
More in black
The common
scenario of SCC
carcinoma in situ
invasive carcinoma
Dysplasia
(full thickness dysplasia)
Risk Factors for SCC of the Esophagus chronic injury to cells
Lifestyle (most important)
directly associated with SCC.
Alcohol consumption
Tobacco abuse
Dietary
Deficiency of trace metals (zinc)
Fungal contamination
of foodstuffs
have a chemical
that is directly
related to
the carcinogenesis of
the squamous cells
Deficiency of vitamins
C
riboflavin,
A
thiamine,
pyridoxine).
High content of
nitrites/nitrosamines-especially
in canned food
Esophageal Disorders:
Achalasia
Plummer-Vinson syndrome
Long-standing esophagitis
Caustic injury (suicide attempt or accident)
Human papillomavirus:
very important role in
squamoproliferative lesions
like
skin and lower
female genital tract
Genetic Predisposition