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Glomerular filtration (Regulation of GFR (Renal autoregulation…

- - - - Decrease renal blood flow, moderate drop in GFR and increased reabsorption of water/salts in PCT
  - - - Smooth muscle cells react to stretching of afferent arteriole to even out the change in local blood pressure on GFR
        
        Vasoconstriction if BP increases
        Vasodilation if BP decreases
    - - Macula densa cells in LOH detect increase in GFR
      - Paracrine signal
      - Constrict arteriole to lower GFR, JG (juxtamedullary) cells decrease production of renin
      - Vice versa for decreased GFR
    - - Local affect to keep BP/filtration normal
      - Maintains GFR during short term and moderate variations in mean arterial pressure
  - - - Increases blood pressure due to:
        Arterioles - Vasoconstriction
        Adrenal cortext -
      - Angiotensin II and GFR
        
        Generalised vasoconstriction has > effect on efferent than afferent
        
        Sharp drop in renal blood flow but filtration maintained
        
        Hydrostatic pressure in perititubular cap. falls increasing tubular reabsorption