Please enable JavaScript.

Coggle requires JavaScript to display documents.

ANTIVIRAL AGENTS (METHODS OF INFECTION (Inhalation - Respiratory tract,…

- - - - Works via phosphorylation by viral enzymes to active state - higher affinity for viral enzymes than host enzymes so less toxic. Then incorporates into viral nucleic acid and STOPS replication
      - Half-life = 2.5 Hrs
      - Crosses blood-brain barrier
      - Excreted by the kidneys - so may have to alter dose if pt has kidney disease
      - Administered TOPICALLY (ointment) or IV (if herpetic encephalitis)
      - Side effects: nausea/headaches; burning sensation when applied
    - - Works via phosphorylation by viral enzymes. Incorporated into viral AND host DNA, so more toxic than Aciclovir
      - Does NOT directly block viral DNA synthesis like Aciclovir
    - - Works by inhibiting viral DNA polymerase - so prevents elongation of chain
      - Can be taken in conjunction with aciclovir and interferon to ENHANCE its effects
      - Administered ORALLY or IV
      - Absorbed in GI tract
      - Metabolized in liver, excreted in kidneys
      - Side effects - ANAEMIA and GRANULOCYTOPAENIA (low white cells), regular bloody cell count every 2 weeks necessary to maintain balance of white cells remaining to fight infection and drug to treat
  - - - Works by inhibiting REVERSE TRANSCRIPTASE enzyme
    - - Works by inhibiting REVERSE TRANSCRIPTASE enzyme
  - - - Alpha
      - Beta
      - Gamma