Please enable JavaScript.
Coggle requires JavaScript to display documents.
Hepatocellular carcinoma (HCC) 2 (yellow-white, punctuated (dots…
Hepatocellular carcinoma
(HCC) 2
yellow-white, punctuated (dots appearance) by bile staining and areas of hemorrhage or necrosis
Unifocal (usually massive).
ll patterns of HCC have a strong propensity for invasion of vascular channel
causing
Diffusely infiltrative
Multifocal (variable sized nodules): related to metastasis
1- Extensive intrahepatic metastases
2- Occasionally snake-like masses of tumor invade the portal vein or IVC extending into the right side of the hear
Microscopic appearance:
Hepatocytes arranged in thick cords, trabeculae or
glandular patterns
Loss of reticulin stain (important sign) collagen
Poorly differentiated (anaplastic or multinucleate tumor giant cells), here we have no cords and no trabeculae
Bile pigment differentiate between a primary tumors and a metastasis
can’t
produce bile pigments
Acidophilic hyaline inclusions resembling undigested keratin and are called Mallory bodies
Profound cachexia
GI or esophageal variceal bleeding
Liver failure
rupture of the tumor with fatal bleeding
Prognosis is better for individuals who have:
< 2 cm in diameter
A single tumor
Good LFT
Causes of death