Amino Acid derived hormones (increase glucose levels in blood…
Amino Acid derived hormones
diabetes (greek for siphon/polyuria)
melitis (latin for sweet/hyperglycemia)
Most common small animal emergency
Pathological consequences of diabetes melitis
3rd leading cause of death in USA.
2nd most common endocrine disease in cats.
3rd in dog.
CANNOT USE GLUCOSE. STARVING CELLS EVEN THOUGH THERE'S PLENTY IN THE BODY
increased gluconeogenesis, increased glycogenolysis, hyperglycemia is the result.
causes weight loss and muscle atrophy
increased fatty acids
increased hepatic acetyl coA
increased ketone bodies
Glucose levels rise
pancreatic beta cells monitor blood sugar
GLUT2 transporter--> results in release of calcium into the cell
insulin released to break down glucose
insulin causes GLUT4 to be placed onto the cell membrane
GLUT4 on cell surface increases glucose transport into the cell
increase glucose levels in blood
Decrease glucose levels in blood