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6 Default Mode Network (Functions (2 hypothesis (sentinal hypothesis…

- - - - parahippocampal cortex (HF+)
    - - ?
  - - - Medial prefrontal subsystem
    - - PCC
        
        connected to medial temporal lobe
- - - - but also glucose mechanism proof
  - - - DMN monitors external world
    - - self reflection
        
        2 subsystems
        
        dMPFC
        
        self reference
        
        medial temporal lob
        
        memory
- - - - PCC/RSP, IPL, LTC
    - - posterior part
    - - prominent in DMN
  - - - increased in DMN because of use
        
        affected memory systems
  - - - medial temporal lobe atrophy
        
        structural
      - medial parietal hypoperfusion
        
        functional
    - - tangles
        
        first in medial temporal lobe
        
        then lateral temporal and parietal
        
        then prefrontal, motor, sensory
      - plaques
        
        first posterior association cortex
        
        then medial temporal
    - - parietal lobe is clearly involved in early AD
      - precuneus/posterior cingualate gyrus is most commonly affected
    - - 20x larger than in monkeys
      - Late to develop
        
        last to be myelinated
        
        Thinner
        
        vulnerable to myelin breakdown and other pathological mechanisms
      - White matter integrity of parietal is highly heriable
    - - Myelin vulnerable
        
        negative effects of genetic/environmental factors
        
        less efficient axons, breaking
        
        neural disconnection posterior cingulate and medial temporal
      - Amloyd plaques
        
        neuronal function decrease
        
        cascade of gray matter atrophy in posterior and medial parietal regions
      - cardiovascular risk causes neurovascular dysfunction
        
        demylination