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Evolutionary Medicine (Mismatch Between Modern and Ancestral Environments,…
Evolutionary Medicine
Mismatch Between Modern and Ancestral Environments
Ancestor features
Lower migration rate
Higher fertility
Less caloric availability
Higher physical activity
Different and greater exposure to infectious disease
Lower exposure to environmental pollutants
Obesity
Sedentary lifestyle
Easier access to calories
Simple starches and refined sugars
Overfed by starving for micronutrients
Microbiota
Breast feeding
Skin cancer
Pale skin
Highest risk (~1000x)
Melanin protects from UV
evolved from Vitamin D3
Now live in UV-rich climes
Melanoma = leading cause of cancer death in 25-40YO males
Evolution of Humans
Aging and Fitness
Menopause
Grandmother effect
Kin networking
Mutation-section balance
Deleterious mutations only affecting elderly
Trade early for late fitness
Antagonistic pleiotropy
Mental Illness
Mental states maximize fitness
Anxiety
Did not evolve to be happy
Surival
Health = balancing act btwn pathologies
continuum from autism to schizophrenia
implies purifying (stabilizing) selection