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Disease of oral cavity (Squamous Cell Carcinoma (SCC) (Most common…
Disease of oral cavity
Squamous Cell Carcinoma (SCC)
arise de novo or as a result of a malignant transformation of
leukoplakia
India and Southeast Asia ; use of “betel
nut” or “areca nut” which is a plant that has alkaloids 40% of this tumor
95% of oral cavity
malignancies and it is the 6th most common malignancy in the world
drinking alcohol and HPV is also a risk factor
most common oropharyngeal malignancy
above age 40 years
significant morbidity
“field cancerization”
second
primary tumor arises since the whole area
is or was subjected to the same carcinogen
Plummer–Vinson syndrome),
epithelial atrophy, immunosuppression, chronic infections (candidiasis, syphilis) and
occupation are risk factors,too.
2 distinctive
pathogenic pathways
Group of tumors mainly in tobacco and alcohol users
genetic mutations P53, P36 and NOTCH1
In tonsillar crypt )
and base of tongue area
oncogenic variants of HPV 16
Most common locations
floor of the mouth
lower
lip
ventral surface of tongue
, soft palate
gingiva
Local recurrence at the primary site or within the neck is the major cause of death
(more metastasis, less
survival rate
n 5-year survival rates
45%-65% for patients with lymph node
metastasis
80% for patients without lymph node metastasis
Seen as
white or red plaque
leukoplakia or erythroplakia
mucosal thickening
mass,
ulcer.
local infiltration then metastasis to
cervical lymph nodes, then mediastinal lymph nodes, lung
and liver