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Diseases of the Salivary Glands (Autoimmune Sialadenitis (secondary (60%)…
Diseases of the Salivary Glands
Viral Sialadenitis
usually affects the parotid gland
70% bilateral parotid, 20% unilateral
Mumps is the most common viral infection in
the salivary gland.
Most common cause is mumps
Mumps virus (or paramyxovirus) is acquired by
respiratory droplets
Mumps virus (or paramyxovirus) is acquired by
respiratory droplets
complications, which are more common in adults
Pancreatitis.
Orchitis(8)
leads to infertility**
CNS inflammation
self-limited
Autoimmune Sialadenitis
90% are females; parotid enlargement in 50%.
primary
(only salivary and
lacrimal glands
antibodies against certain tissues
that are mainly the salivary and lacrimal glands.
lacrimal glands
dry
eyes or keratoconjunctivitis sicca
Many findings
Positive RF (rheumatoid factor), ANAs (antinuclear antibodies) and +/-;
antiribonucleoprotein SS-A & SS-B antibodies.
Lymphocytic infiltration and fibrosis
inflammation of salivary glands and
mucus-secreting glands of nasal mucosa
dry
mouth or xerostomia
Sjögren’s
syndrome
secondary (60%) to other autoimmune
diseases
high risk to develop
lymphomas
polymyositis.
SLE,
RA