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Antibiotic MOA (Inhibition of Cell Wall Synthesis Works good with…
Antibiotic MOA
Inhibition of Cell Wall Synthesis
Works good with Gram + Selective and
Bacteriocidal
Prevent Teichoic Acid Crosslinking
Peniciliins
Naturals
Narrow Spectrum
Penicillin G
Injected
Penicillin V
most acid stable
Semi-Synthetics
Broader spectrum
Ampicillin
broader spectrum
works on many gram-
Amoxiciliin
Narrow spectrum
only gram +
Semi-synthetics w K+ clavulanate
product of
Streptomycete
Augmentin
when combined with
amoxicillin
Semi-Synthetics w carbapenems
works for 98% of HAIs
Broad spectrum
Primaxin
combination of imipenem and cilastin
longer lasting
Semi-synthetics w/ only one ring
Monobactims
No beta-lactum ring
immune to penicillinases
Low Toxicity
aztreonam
Good for
Pseudomonas
and
E. Coli
Cephalosporins
Cephalo-Wonderfuls
more expensive
Broader spectrum
Keflex
New generations
Interfere with Synthesis of Linear peptidoglycan
strands
Interferes with Nag-Nam
Vancomycin
"Big Gun"
Bacitracin
-Topical use
Isoniazid (INH)
Good against
Mycoplasma
Ethambutol
synthetic, used as secondary drug
Inhibition of Protein Synthesis
Bacteriostatic
Chloramphenicol
50s subunit
Broad Spectrum
good for bacterial meningitis and
Salmonella typhii
Causes aplastic anemia
Small molecular weight
Tetracyclines
30s subunit
Broad Spectrum
Works on
Rickettsias
and
Chlamydias
Brownish teeth in children
Photosensitivity
liver damage in pregnant women
added to animal feed for weight gain
Erythromycin
50s subunit
good for gram +
Aminoglycocides
bactericidal
Changes 30s subunit shape
cause permanent damage to hearing and kidneys
Streptomycin
Gentamycin
Neomycin
Inhibition of Nucleic Acid Replication
More risky
Bactericidal
Rifamycin
Inhibits Transcription
Penetrates tissue well
Turns fluids orange
works against gram + and TB
Injury to Plasma Membrane
Metabolites are lost thru membrane
Good for Gram negative
Polypeptide Antibiotics
Very large
Bactericidal
Polymyxin B
Disrupts membrane integrity
Inhibit Enzymatic Activity
mimics normal substrate
Bacteristatic
Sulfanilamide
blocks PABA