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thrombosis (causes (endothelial injury (most important factor predisposing…
thrombosis
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causes
endothelial injury
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exposure of subendothelial collagen causes platelets to adhere, release of tissue factor, localized depletion of prostacyclin and plasminogen activator (plasmin degrades fibrin)
this causes a distruption of the balance between the pro-thrombotic and anti-thrombotic properties of endothelial cells
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hypercoagulability
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secondary (acquired): both arterial and venous, caused by numerous disorders
locations of thrombi
arterial thrombi
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common sites: coronary a, cerebral a, femoral a
venous thrombi
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common sites: veins of lower extremities, gonadal veins
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