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hemostasis (depends on (plateles (secretion: they release pro-binding…
hemostasis
depends on
plateles
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aggregation: fibrinogen links platelets via GpIb, platelets secrete thromboxane (TXA2), ADP, and aggregating factors
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coagulation cascade: the point of this cascade is to activate thrombin which cleaves fibrinogen into insoluble fibrin
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coagulation cascade
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cofactors: Ca2+, vitamin K, VIIIa (active factor 8), V (active factor 5)
coagulation inhibition
heparin (endothelial bound proteoglycans) work by blocking Antithrombin III which inhibits activation of cofactors and ultimately thrombin
thrombomodulin + thrombin together activate proteins C and S which leads to no VIII and V being produced
plasmin (which is the active form of plasminogen) degrades fibrin (insoluble) into fibrin degradation productions (FDPs)
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well regulated process to maintain blood in fluid, clot FREE state and induce a rapid an localized hemostatic plug at the site of vascular injury