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Anti-neoplastic Antibodies (Mechanism of Action (Anthracyclines)…
Anti-neoplastic Antibodies
Subclasses
Mytomycin
Bleomycin
Anthracyclins (
Doxorubicin
)
About
High toxicity -> not used with radiotherapy
Interrelate between specific DNA bases
Cell-cycle independent
Mechanism of Action (Anthracyclines)
Interchelate in DNA (block DNA+RNA synthesis, DNA strand scission)
Generate free radicals
Inhibit Topo II
Bind to cell membranes (alter fluidity + ion transport)
Acquired Resistance
Tenfold cross resistance with cisplatin (AP2780 CP70)
Increased drug transporters
Complex interactions between amplified TOPIIA gene expression and neighboring HER-2 gene
Side Effects (anthracyclins)
Alopecia
Nausea/vomiting
Necrosis at IV site
Cardiotoxicity (ROS from doxorubicinol and/or mitochondrial dysfunction)