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Disinfectants, antiseptic (Phenols (Destroy selective permeability of cell…
Disinfectants, antiseptic
Disinfectants kill or inhibit the growth of microorganisms on inanimate objects
Antiseptics kill or inhibit the growth of microorganisms on animate objects
easy to apply, Not damage or stain, nonirritating, Have the broadest possible spectrum of activity, affordable, Stable and not easily inactivated after application
Keep in mind
- application surface
- range of org to eliminate
- apply products on thoroughly clean surface (some less effective w presence of organic waste)
- read package insert: dilution recommendations, special use instructions
- contact time: critical to efficacy of product
- keep MSDS
Phenols
Destroy selective permeability of cell memb
Effective against G+ but generally ineffective against G- bac, fungi, some enveloped virus
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- X easily inactivated by organic material
- slower onset of action compared to povidone and chlorohexidine
- prolonged contact may damage skin
- neurotoxicity (CNS) risk
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Aldehydes
Work against protein structure
Effective against G+ and G- bac, fungi, virus, bact spores
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not inactivated by organic material, hard water
expensive, short shelf life
toxic in tissue
Ethylene oxide
Destroy DNA and protein
Gas for chem sterilization
Effective against G+ and G- bac, fungi, viruses, bact spores
Alcohol
Coagulate proteins, dissolve memb lipids
Effective against G+ and G- bact, fungi, env virus
Low cost, low toxicity
ineffective against spores
must sufficient quantity and stay in contact w site for 7s for effective
dun put on open wound
dissolve coagulum and may cause entry of bac- infxn
dry up skin at repeated usage
Halogens
Interfere protein, enzyme
Chlorine
- kills bac, fungi, viruses (env and non-env)
- ineffective against bac spore
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- corrosive at fabric and metals
- largely inactivated by organic material
- contact w site several min to ensure destroy pathogens
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Biguanides
Denature protein
Effective against G+ and G- bact, bact spores, fungi, virus
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selection:
- type of microbe to eliminate agent
- environment which disinfectant will used
- charactheristic of disinfectants: evaporation, corrosion, cost, spectrum of activity etc
hydrogen peroxide
damages protein, kill anaerobic bac
causes tissue damage- limited use
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