In roedents: results in a small, lean rodent, with impaired fertilty, which otherwise healthy and active and lives as much as 40% longer. Less body fat, smaller organs, more active (to search for food). There is no normal age-related decrease in physical activity (less tumours, less decrease in wound-healing and elimination of autoimmune disease => up-regulation mechanisms protecting again accumulation of somatic damage. ==> in general: extends maximum longevity and slows ageing