Please enable JavaScript.
Coggle requires JavaScript to display documents.
Inflammation (Cytokines (IL-6 (T-cell activation, Stimulates acute phase…
Inflammation
Cytokines
IL-6
T-cell activation
Stimulates acute phase protein synthesis
Produced by T cells
IL-8
Recruits immune cells to site of release
Produced by; monocytes & macrophages
IL-1
Produces Fever
Produced by: monocytes
Stimulates acute phase protein synthesis
Tumor Necrosis Factor (TNF) aplha
Activates macrophages
Induces fever and septic shock
Produced by; macrophages & mast cells
Systemic Changes
Behavioural
Sleepiness
Appetite
Depression
Immune cell produciton
Increased leukocyte production
Acute Phase Protein Production
Soluble PRR's
Iron Binding Proteins
Clotting Factors
Induction of Fever
Changes in the Hypothalamus
PAMPS
Recognise patterns on the surface of pathogens
Pathogen Associated Molecular Patterns
Highly conserved chemical structures
PRR (pathogen recognition receptors)
Binding to PAMPS=
Leads to activation and nuclear translocation
Nuclear Factor-kB (NF-kB)
NF-kB
= mater switch that turns on inflammatory cytokines
30-60 min
Inflamm Pathways
2)
Min to hours
=
neutrophils
(norm circulate in blood) attracted to site
3)
Squeeze
- (
extravasate
) the endothelium through
diapedesis
- allows large numbers of neutrophils to infiltrate affected tissue (results in pus)
1)
30-60 min
=
Cytokines
*
produced
4)
Monocytes
attracted= mature to
DC'
s and they capture antigens and take them to the nearest lymph node- T cell match and proliferate- back to area
TO END
Macrophage signals change to wound healing
Anti-inflammatory cytokines IL-10
Growth factor
Inflammatory Disorder
Asthma
Tuberculosis
Chrons Disease
Pro-Inflamatory Factors Changes
LOCAL
Tissue destruction
(allowing room for cell infiltration)
Infiltration of immune cells
(neutrophils, monocytes & lymphocytes)
Vascular Endothelium
(blood vessel walls)
Activation of local clotting
factors (preventing further spread of infection)
SYSTEMIC
Activation of Blood Vessels
Increased Lymphatic Circulation
Increased Haematopoiesis
(making RBC's)
Fever
Metabolic Changes
Production of acute phase proteins
(C-reactive proteins)