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Hormone Antagonists (Aromatase inhibitors (Anastrazole, MoA: Suppress…
Hormone Antagonists
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SERMS
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Tamoxifen MoA: competes with endogenous oestrogens without inducing conformational change + cooactivator binding. Inhibits growth
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Oestrogenic actions on bone, plasma lipids & endometrium (good for post menopause bones), decreases circulating cholesterol (liver), increases risk endometrial cancer
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Breast Cancer
Subgroups
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Basal-like (triple negative, bad outcome)
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Luminal A (ER +/or PR, HER2 -ve, best outcome)
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