Please enable JavaScript.
Coggle requires JavaScript to display documents.
cytogenetics (types of structural rearrangements of chrs (balanced (no…
cytogenetics
-
types of translocations
-
Reciprocal translocation
-
there is no loss or gain of genetic information, there is no phenotype effect (unless there is a position effect resulting in gene disruption)
-
-
euploidy (lethal in humans); addition or loss of an entire set of chromosome (triploidy: 69 chrs vs tetrapolidy: 92 chrs)
aneuploidy: gain or loss of a single chromosome; usually a failure in meiosis (monosomies: loss of 1 chr vs trisomies: gain of 1 chr)
trisomy 13: 3 chrs 13; polydacty, cleft lip and plalate
trisomy 18: clenched fists, malformed ear
CML (chronic myeloid leukemia) results from a translocation between chromosome 9 and 22 (Philadelphia translocation)
-