Accuracy in data classification depends on the dataset used for learning. Now-a-days the most important cause of death for both men and women is due to the Liver Problem. The healthcare industry collects a huge amount of data which is not properly mined and not put to the optimum use. Discovery of these hidden patterns and relationships often goes unexploited. Our research focuses on this aspect of Medical diagnosis by learning pattern through the collected data of Liver disorder to develop intelligent medical decision support systems to help the physicians. In this paper, we propose the use decision trees J48, Naive Bayes, ANN, ZeroR, 1BK and VFI algorithm to classify these diseases and compare the effectiveness, correction rate among them. Detection of Liver disease in its early stage is the key of its cure. It leads to better performance of the classification models in terms of their predictive or descriptive accuracy, diminishing of computing time needed to build models as they learn faster, and better understanding of the models. In this paper, a comparative analysis of data classification accuracy using Liver disorder data in different scenarios is presented. The predictive performances of popular classifiers are compared quantitatively.