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Support tissues - Bone (Functions of bone (Support, Protection, Movement,…

- - - - Matures into osteocyte
        
        Surrounded by own matrix
        
        Dormant
      - Produce ECM (bone matrix) [osteoid]
      - Found in periosteum (fibrous layer surrounding outside of bone) and endosteum (cellular layer lining bone cavity)
      - Maintain bone tissue
    - - Macrophage
        
        Phagocytic properties
      - Derived from monocytes
      - Fusion of many macrophages, multinucleate and large. Ruffled border
      - Destroy bone matrix for:
        
        General turnover of bone
        
        Re-modelling of bone during growth
        
        Fracture repair
        
        Response of bone to changing mechanical stresses
        
        Increasing Ca2+ levels in blood
- - - - Solid or cortical
      - Outer shell of bone
      - In longitudinal section: Osteocyte lacunae appear as elongated brown specks arranged in concentric layers around Haversian canals
    - - Epiphysis
      - Trabecular or cancellous
  - - - Long bones a macroscopic cylinder, with walls made of microscopic cylinders
    - - Extending cells processes in matrix
      - Contact between osteocytes
- - - - Development of centre of ossification
        
        Calcification
        
        Formation of trabeculae
        
        Development of periosteum
      - Trabcules forming as bone matrix 'islands' join together forming little bridges
  - - - "Cartilage template"
      - During growth new cartilage formed continuously at growth plate
      - Cartilage is replaced NOT converted to bone
      - Cartilage -> Woven -> Lamellar
      - Secondary centres of ossification
      - Hyaline cartilage between primary and secondary centres. The growth plate
      - Growth plate Histology
        
        Divided into zones
        
        Chondrocytes change morphology
        
        Alive in epiphysis
        
        Dead in calcified cartilage